Presentation entitled ‘’Economic and ecologic evaluation: Comparing continuous and batch based purification strategies’’ by Alessandro Luigi Cataldo, Peter Satzer and Alois Jungbauer.

Presentation entitled ‘’Next generation downstream process – manufacturing of biologics in a continuous way’’ by Gorazd Hribar.

Presentation entitled ‘’Robust Units, Constant Product Mass Flow and How Alternative Purification Methods Can Achieve Both for Antibody Production’’ by Peter Satzer.

Presentation entitled Factorization of Preparative Protein Chromatograms with Hard-Constraint Multivariate Curve Resolution and Second Derivative Pretreatment by Matthias Rüdt, Sebastian Andris, Robin Schiemer, Jürgen Hubbuch (KIT).

Presentations entitled Case Study: Continuous connected downstream processing by Luka Jeromel (LEK), Continuous purification of antibodies by P.Satzer, D. Burgstaller, W.Krepper, A. Cataldo, A. Jungbauer (BOKU).

Presentation entitled Leveraging Light: Spectroscopy as a PAT Tool for Biologics by Matthias Rüdt, Sebastian Andris, Steffen Grosshans, Nils Hillebrandt, Jonas Rogalla, Adrian Sanden, Philipp Vormittag, Jürgen Hubbuch (KIT).

Presentation entitled Thermosensitivity of Protein A Affinity Media by W. Krepper, P.Satzer, B. Beyer, A. Jungbauer (BOKU). Presentations entitled Water on Hydrophobic Surfaces: Mechanistic Modeling of Polyethylene Glycol Induced Protein Precipitation by Steffen Großhans, Gang Wang, Juergen Hubbucht (KIT) and Process analysis for preperative protein chromatography using in-line attenuated total refelction fourier transform infrared spectroscopy by Adrian Sanden, Nina Brestrich, Steffen Grosshans, Josefine Morgenstern, Matthias Rüdt, Stefan Heissler, Jürgen Hubbuch (KIT).

Presentations entitled Next generation Downstream Processing (NextBioPharm) by Peter Satzer and team (BOKU), Interconnected protein precipitation and precipitate harvest by Daniel Burgstaller and team (BOKU), Economic evaluation: Comparing different scenarios of primary recovery and capture steps of recombinant monoclonal antibody production by Alessandro Luigi Cataldo and team (BOKU).

Presentation entitled Challenges and novel engineering solutions for the emerging biotechnological processes by Uroš Novak, Miha Kastelic, Blaž Likozar (KI).

Presentation entitled Next Generation Biopharmaceutical Downstream Process – an EU Horizon 2020 Funded Research and Innovation Programme by Michael Phillips.

Presentations entitled Thermosensitivity of Protein A Affinity Media by W. Krepper, P.Satzer, B. Beyer, A. Jungbauer (BOKU) and Continuous antibody precipitate harvest by two-stage tangential flow filtration by D. Burgstaller, P.Satzer, W.Krepper, A. Jungbauer (BOKU).

Presentations entitled Next Generation Downstream Processing for mAbs Production by Marine Maszelin, Josselyn Haas (both MM) and Continuous integrated antibody production – Primary separation and non-chromatographic capture by P.Satzer, D. Burgstaller, W.Krepper, A. Cataldo, A. Jungbauer (BOKU).

Presentation entitled Continuous downstream strategies for future processes by Helena Trnovec.

Presentation entitled Continuous Processing Strategies - nextBioPharmDSP by Gorazd Hribar.

Presentation entitled Next Generation Downstream Processing for mAbs Production by Marine Maszelin, Nicolas Laroudie (both MM).

Presentations entitled: Water on Hydrophobic Surfaces: Mechanistic Modeling of Polyethylene Glycol Induced Protein Precipitation; Artificial intelligence in protein chromatography: Root cause investigation of process deviations; Monitoring and control of capture steps by PLS modeling and spectroscopy; In-line Fourier-Transform Infrared Spectroscopy as a Versatile Process Analytical Technology for Preparative Protein Chromatography; Monitoring and control of capture steps by PLS modeling and spectroscopy. All done by KIT team: Steffen Großhans, Gang Wang, Matthias Rüdt, Jürgen Hubbuch and others.

Presentation entitled Analyzing Protein UV/Vis Chromatograms with PLS Models and Calibration-free Methods by Matthias Rüdt.

Presentation entitled Continuous integrated protein precipitation – Is there a need for steady state? By D.Burgstaller, P.Satzer, S.Caserman, A.Jungbauer (BOKU and KI).

Presentation entitled Continuous processing approaches by Gorazd Hribar (LEK).

Presentation entitled Model-based Process Optimization for Upstream Bioreactor Production–Downstream Chromatographic Separation of CHO Cell Monoclonal Antibodies (mAb) presented by Matic Grom, Blaž Likozar and other colleagues from KI.

Presentations entitled Continuous Downstream Processing, Do We Need To Operate At Steady State? By P.Satzer, W.Krepper, D.Burgstaller, A.Jungbauer (BOKU) and Continuous protein precipitation – A simple and robust antibody capture step by D.Burgstaller, P.Satzer, W.Krepper, A.Jungbauer (BOKU).

Presentation entitled 3D structure of protein precipitates, fractal dimension and influence of batch and continuous precipitation on the 3D structure by P.Satzer, D.Burgstaller, A.Jungbauer (BOKU).

Presentation entitled Next-generation Biopharmaceutical Downstream Process by Blaz Likozar and his team from KI.

Presentation entitled Continuous protein precipitation–A robust antibody purification methodwithout the need for steady state conditions during continuous integrated production by D.Burgstaller, P.Satzer, S.Großhand, S.Caserman, A.Jungbauer (BOKU).

Poster entitled ChromatographyNovel Protein A Chromatography Resin Enables Elution by Heat, Salt and Acid by authors W. Krepper, P. Satzer and A. Jungbauer.

Presentation entitled Calibration of mechanistic chromatography models using artificial intelligence by Gang Wang, Till Briskot, Tobias Hahn, Pascal Baumann, Jürgen Hubbuch (KIT).

Presentation entitled Thermodynamic properties of Staphylococcal Protein A – Antibody Interaction by authros W. Krepper, P. Satzer and A. Jungbauer.

Presentation entitled Biothermodynamics of Protein A IgG interaction by authors W. Krepper, A. Jungbauer and P. Satzer.

Presentations entitled: Simulated Periodic Counter-Current Chromatography (sPCCC) – a scale-down model for multicolumn continuous chromatography process development; In-line FTIR as a versatile PAT tool for downstream processing of proteins; Deconvolution of UV/Vis chromatograms with PLS models and calibration-free methods; Real-time monitoring and control of the load phase of a protein A capture step. All done by KIT team: Steffen Großhans, Gang Wang, Matthias Rüdt, Jürgen Hubbuch and others.

Presentation entitled Single-Pass and Single-Use TFF Comparison to Conventional TFF for High Protein Concentrations by author Dejan Arzensek.

Presentation entitled Possibilities for integrated continuous downstream process by presenter Helena Trnovec (Lek).

Presentations entitled Exploring PAT approaches for Ultrafiltration/Diafiltration as the first step to continuous process design by Dejan Arzensek (Lek), presentation Continuous in line flocculation, new opportunities for primary separation and economic impact by Peter Satzer (BOKU), presentation Real-time monitoring of critical quality attributes and process parameters by spectroscopy during chromatographic capture and polishing steps by Matthias Rüdt, Nina Brestrich, Daniel Büchler, Laura Rolinger Adrian Sanden and Jürgen Hubbuch (all KIT) and presentation Integrated precipitation and periodic counter-current chromatography process by Steffen Großhans, Gang Wang, Christian Fischer, Pascal Baumann and Jürgen Hubbuch (all KIT). Poster entitled Artificial intelligence in protein chromatography: Estimation of mechanistic model parameters by authors Gang Wang, Till Briskot, Pascal Baumann, Tobias Hahn and Jürgen Hubbuch (all KIT).

Presentations entitled Membrane adsorbers and flow-through approaches for continuous processing by Helena Trnovec (Lek) and Next-generation biopharmaceutical downstream process by Luka Jeromel (Lek).

Presentation entitled Continuous DSP Strategies - nextBioPharmDSP by presenter Gorazd Hribar (Lek).

Presentation of project nextBioPharmDSP content, impacts and discussions led by Gorazd Hribar (Lek) and Peter Satzer (BOKU).

Presentations entitled Next Generation Biopharmaceutical Downstream Process by Gorazd Hribar (Lek) and Fast and easy way to boost your primary separation in mAb production: Continuous flocculation, new alternatives for old problems bpresented by Peter Satzer. Posters entitled Membrane adsorbers for continuous processing by authors Helena Trnovec, Tibor Doles, Gorazd Hribar (all Lek) and Performance Comparison of Protein A Affinity Chromatography Sorbents at Different Temperatures by authors Walpurga Krepper, Peter Satzer, Alois Jungbauer.

Presentation entitled Development of a robust Ultrafiltration/Diafiltration step for highly concentrated drug substance using process analytical methods and aggregation modelling by author Dejan Arzensek (Lek).

Presentation entitled Continuous capture of antibodies: from laboratory to pilot scale by author Alois Jungbauer.

Presentations entitled PAT for preparative chromatography of proteins: real-time monitoring of a capture and polishing step by authors Matthias Rüdt, Nina Brestrich, Daniel Büchler, Adrian Sanden, Jürgen Hubbuch (all KIT) and Simulated Periodic Counter-Current Chromatography (sPCCC) – a scale-down model for multicolumn continuous chromatography process development by authors Gang Wang, Till Briskot, Matthias Rüdt, Jürgen Hubbuch (all KIT). Poster entitled Capturing of monoclonal antibodies by continuous precipitation as an alternative for conventional affinity chromatography by auhors Daniel Burgstaller, Peter Satzer,Walpurga Krepper (all BOKU),Steffen Großhans (KIT), Jure Mohoric, Katja Pajnic (both LEK), Alois Jungbauer (BOKU).

Poster entitled Continuous downstream processing of recombinant antibodies based flocculation and precipitation by authors Peter Satzer, Daniel Burgstaller, Nico Lingg, Beate Hintersteiner, Nikolaus Hammerschmidt, Alois Jungbauer (all BOKU).

Presentation entitled Going continuous: The use of cell flocculation for continuous primary recovery of recombinant monoclonal antibody production by authors Daniel Burgstaller, Peter Satzer (both BOKU), Josselyn Haas, Marine Maszelin (both MM), Jure Mohoric, Katja Pajnic (both Lek), Alois Jungbauer (BOKU).

Presentation entitled Parallelizable Microfluidic Resistive On-Line Detector of Micrometric Aggregates of Biopharmaceutical Antibodies by authors M. Carminati, M. Giacometti, M. Sampietro, S. Chiodini, G. Ferrari (all NSYS), Doles Tibor (Lek).

Presentation entitled NextBioPharmDSP – Next Generation biopharmaceutical downstream process with overview of consortium and recent results held by Christopher Gillespie (MM) and presentation entitled Establishing a mAb flow through polishing process: Evaluation of new materials with authors Mathilde Bourguignat, Nicolas Laroudie, Christopher Gillespie (all MM) focused on flow through purification.

Poster presented with title Application of PAT in Chromatography: From Capture to Polishing by authors Nina Brestrich, Matthias Rüdt, Laura Rolinger, Jürgen Hubbuch.

Workshop organised entitled Towards continuous bioprocessing held by Gorazd Hribar, Dejan Arzensek (both Lek), Christine Idrissi, Frederic Sengler (both MM).

Presentation entitled Next Generation Biopharmaceutical Downstream Process held by Tibor Doles (Lek) and poster entitled Continuous Flocculation of Culture Broth for Primary Recovery of Antibodies by authors Peter Satzer (BOKU), Lise Besnard (MM), Alois Jungbauer (BOKU).

Presentation entitled Spectral deconvolution of chromatograms with PLS models and calibration-free methods by authors Matthias Rüdt, Nina Brestrich, Jürgen Hubbuch (KIT).

Presentation entitled Productivity and economic impact of continuous processing of antibodies held by Alois Jungbauer (BOKU).

Poster entitled Spectral Deconvolution of Chromatograms without Offline Analytics by authors Matthias Rüdt, Nina Brestrich, Jürgen Hubbuch from KIT.

Presentation entitled Next-Generation Biopharmaceutical Downstream Processes - Continuous Bioprocessing held by Gorazd Hribar (Lek) and Christopher Gillespie (MM).