Publications

 
  • 01.08.2017

    ROOT CAUSE INVESTIGATION OF DEVIATIONS IN PROTEIN CHROMATOGRAPHY BASED ON MECHANISTIC MODELS AND ARTIFICIAL NEURAL NETWORKS

    Authors Gang Wang, Till Briskot, Tobias Hahn, Pascal Baumann and Jürgen Hubbuch published scientific publication entitled Root cause investigation of deviations in protein chromatography based on mechanistic models and artificial neural networks in Journal of Chromatography A.
    Main highlights:
    • Simulations of potential process deviations based on a mechanistic model were used to construct an artificial neural network model. Experimental errors in ionic capacity and salt gradient length were imitated simultaneously to prove the practical capability of this method. 
    • By this approach, the time-consuming root cause investigation itself could be reduced down to milliseconds. This approach could be a building block for real-time root cause investigation in chromatography processes. 
    Link: https://doi.org/10.1016/j.chroma.2017.07.089
     
  • 03.03.2017

    ESTIMATION OF ADSORPTION ISOTHERM AND MASS TRANSFER PARAMETERS IN PROTEIN CHROMATOGRAPHY USING ARTIFICIAL NEURAL NETWORKS

    Authors Gang Wang, Till Briskot, Tobias Hahn, Pascal Baumann and Jürgen Hubbuch published scientific publication entitled Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks in Journal of Chromatography A.
    Main highlights:
    • Simulations based on an uncalibrated mechanistic model were used to construct an artificial neural network model. 
    • The calibrated artificial neural network model was employed to predict mass transfer and adsorption isotherm parameters for three proteins. 
    • The predicted parameter sets were used to predict gradient elution runs, which were validated in the laboratory. 
    • This approach could support calibration purposes in mechanistic modeling in general. 
    Link: https://doi.org/10.1016/j.chroma.2017.01.068
     
  • 04.01.2017

    PARALLELIZABLE MICROFLUIDIC RESISTIVE ON-LINE DETECTOR OF MICROMETRIC AGGREGATES OF BIOPHARMACEUTICAL ANTIBODIES

    Authors M. Carminati, M. Giacometti, M. Sampietro, S. Chiodini, T. Doles and G. Ferrari published scientific publication entitled Parallelizable Microfluidic Resistive On-Line Detector of Micrometric Aggregates of Biopharmaceutical Antibodies in Procedia Engineering.
    Link: https://doi.org/10.1016/j.chroma.2016.11.010
     
  • 14.12.2016

    NEW PRODUCTION PROCESSES PROMISE TO LOWER COST OF BIOPHARMACEUTICALS

    Directorate General for Research and Innovation within EU published article entitled New production processes promise to lower cost of biopharmaceuticals.
    Link: http://ec.europa.eu/research/infocentre/article_en.cfm?artid=42436
     
  • 15.11.2016

    Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology

    Authors Matthias Rüdt, Till Briskot, Jürgen Hubbuch published scientific publication entitled Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology in Journal of Chromatography A. http://dx.doi.org/10.1016/j.chroma.2016.11.010
     
  • 20.08.2016

    Real-time monitoring and control of the load phase of a protein A capture step

    Authors Matthias Rüdt, Nina Brestrich, Laura Rolinger, Jürgen Hubbuch published scientific publication entitled Real-time monitoring and control of the load phase of a protein A capture step in journal Biotechnology and Bioengineering (DOI: 10.1002/bit.26078). 
    http://onlinelibrary.wiley.com/doi/10.1002/bit.26078/abstract