Publications

Authors Gang Wang, Till Briskot, Tobias Hahn, Pascal Baumann and Jürgen Hubbuch published scientific publication entitled Root cause investigation of deviations in protein chromatography based on mechanistic models and artificial neural networks in Journal of Chromatography A.
Main highlights:

• Simulations of potential process deviations based on a mechanistic model were used to construct an artificial neural network model. Experimental errors in ionic capacity and salt gradient length were imitated simultaneously to prove the practical capability of this method. 
• By this approach, the time-consuming root cause investigation itself could be reduced down to milliseconds. This approach could be a building block for real-time root cause investigation in chromatography processes. 

Link: https://doi.org/10.1016/j.chroma.2017.07.089

Authors Josefine Morgenstern, Gang Wang, Pascal Baumann and Jürgen Hubbuch published scientific publication entitled Model‐Based Investigation on the Mass Transfer and Adsorption Mechanisms of Mono‐Pegylated Lysozyme in Ion‐Exchange Chromatography in Biotechnology Journal.

Authors Gang Wang, Till Briskot, Tobias Hahn, Pascal Baumann and Jürgen Hubbuch published scientific publication entitled Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks in Journal of Chromatography A.
Main highlights:

• Simulations based on an uncalibrated mechanistic model were used to construct an artificial neural network model. 
• The calibrated artificial neural network model was employed to predict mass transfer and adsorption isotherm parameters for three proteins. 
• The predicted parameter sets were used to predict gradient elution runs, which were validated in the laboratory. 
• This approach could support calibration purposes in mechanistic modeling in general. 

Link: https://doi.org/10.1016/j.chroma.2017.01.068

Authors M. Carminati, M. Giacometti, M. Sampietro, S. Chiodini, T. Doles and G. Ferrari published scientific publication entitled Parallelizable Microfluidic Resistive On-Line Detector of Micrometric Aggregates of Biopharmaceutical Antibodies in Procedia Engineering.
Link: https://doi.org/10.1016/j.chroma.2016.11.010

Directorate General for Research and Innovation within EU published article entitled New production processes promise to lower cost of biopharmaceuticals.
Link: http://ec.europa.eu/research/infocentre/article_en.cfm?artid=42436

Authors Matthias Rüdt, Till Briskot, Jürgen Hubbuch published scientific publication entitled Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology in Journal of Chromatography A. http://dx.doi.org/10.1016/j.chroma.2016.11.010